Re2O vs Rejuran vs Juvelook: Longest Lasting?

When researching Skin boosters, RE2O, Rejuran, and Juvelook tend to appear together as a trio. It's tempting to line them up and ask which one lasts the longest — but since each contains entirely different active ingredients, the way their results unfold is fundamentally different.

> This article is an informational content piece prepared by Beautystone Clinic in Hongdae.

To put it briefly: Juvelook uses PDLLA* to gradually stimulate Collagen production, Rejuran uses PN* to support the skin's recovery signaling, and RE2O is a relatively newer approach based on hADM* for structural reinforcement — with limited published data so far. All three work through cumulative sessions rather than delivering immediate full results, which means the more important question isn't "how long does one session last?" but rather "how should I space my sessions?"

PDLLA*: A lactic acid-based microparticle that slowly biodegrades within the skin, stimulating the body's own Collagen synthesis. Commonly used in Collagen-boosting procedures like Juvelook.

PN* (Polynucleotide): A DNA-derived ingredient extracted from sources such as salmon. Known to be involved in skin recovery signaling and tissue repair.

hADM* (Human Acellular Dermal Matrix): A matrix-based ingredient used to reinforce the structural integrity of the Dermis.

What you'll learn from this article

  · How the ingredients in each Skin booster differ
  · Why their duration of effect appears different
  · Which option may be better suited to your skin condition
  · How to determine the ideal spacing between sessions

Each One Contains a Different Active Ingredient

Even though all three fall under the Skin booster category, the ingredients working beneath the surface are entirely distinct. Sharing a category name doesn't mean sharing the same results or skin texture outcomes.

The core of the Juvelook lineup is PDLLA — lactic acid-based microparticles that slowly biodegrade within the skin, prompting your body to produce its own Collagen. The U.S. National Library of Medicine describes how lactic acid-based particles stimulate new Collagen formation as they break down. Rather than filling immediately, results emerge gradually over time.

Rejuran's core ingredient is PN. Polynucleotides and related compounds are DNA-derived substances, and published review data indicate their involvement in fibroblast activity, tissue repair, and anti-inflammatory signaling. The effect leans more toward elevating the skin's overall recovery tone rather than adding volume.

RE2O takes an approach centered on hADM, aiming to reinforce the structural integrity of the Dermis itself. However, compared to the other two ingredients, clinical data available to the public remains limited — which means variability in outcomes may be greater from person to person.

Why Their Duration of Effect Appears Different

The reason it's difficult to summarize their duration in a single statement is that all three work through fundamentally different mechanisms from the start. A procedure that fills, one that supports recovery, and one that reinforces structure simply cannot follow the same timeline.

The Juvelook lineup works by gradually stimulating Collagen as PDLLA biodegrades — results tend to emerge slowly and persist for a comparatively longer period. Rejuran's recovery signaling operates on shorter cycles, so changes between sessions can feel more noticeable earlier, but regular maintenance sessions are generally recommended to sustain cumulative benefits. RE2O works through progressive structural reinforcement, and given the limited available data, it's wise to approach it with broader expectations regarding outcome variability.

The American Society for Dermatologic Surgery notes that Collagen-stimulating procedures typically show gradual results over 3 to 6 months, with the number of sessions needed varying by individual. Even with the same procedure, factors like Collagen synthesis rate and lifestyle habits — UV exposure, sleep, and diet — all influence how long results last. The comparison below reflects general tendencies only; your individual experience may differ.

Which Option May Suit Your Skin Condition

Narrowing down based on the most prominent signals your skin is showing can make the decision a bit clearer. Even two people in their late 30s can have very different starting points — one with rough Skin Texture and one with loss of volume.

• Rough Skin Texture and slow recovery: Rejuran may be the closer match. Since PN is involved in recovery signaling, improvements in Skin Texture tone tend to become noticeable relatively quickly.
• Loss of both volume and Elasticity: The Juvelook lineup may be more appropriate. PDLLA gradually supports volume restoration alongside Collagen stimulation.
• Noticeable weakening of dermal structure: RE2O may be worth considering. It takes an hADM-based approach to reinforce the structural layer of the Dermis.
• Sensitive skin or frequent Swelling: It's advisable to first consult about lineups with reduced discomfort or recovery signal-based procedures.

It's also worth referencing guidance from the American Society for Dermatologic Surgery, which notes that the duration of injectable and Filler-based procedures can range from 6 months to 2 years depending on the product type and technique used. Rather than one option being universally correct, the goal is finding the approach that aligns most closely with your skin's own signals.

At Beautystone Clinic in Hongdae, Session Intervals Are Tailored to Your Skin's Recovery

At Beautystone Clinic in Hongdae, even when the same Skin booster is used, the session interval is determined only after assessing how your skin is recovering. For those who recover quickly, standard intervals are applied; for those with slower recovery or a history of frequent procedures, slightly longer gaps are built in to allow the Dermis adequate time to recover. The clinic is within walking distance of Hapjeong Station, making it convenient to stop by between sessions for a quick check-in and schedule adjustment.

How to Determine the Right Spacing Between Sessions

The ideal interval between sessions depends on your skin's recovery pace and the specific procedure. General recommendations serve as a reference point — adjusting based on how your recovery tone progresses is always the safer approach.

Procedure	Key Ingredient	Mechanism	Recommended Sessions (General Tendency)
Juvelook Lineup	PDLLA (lactic acid-based)	Gradually stimulates Collagen production	3–4 sessions, every 4 weeks
Rejuran Lineup	PN (Polynucleotide)	Supports skin recovery signaling	3 sessions every 4 weeks, followed by maintenance sessions
RE2O	hADM (Acellular Dermal Matrix)	Reinforces dermal structure	3 sessions, every 4–6 weeks

If sessions are spaced too closely together, the next procedure may overlap before the previous session's effects have fully developed, potentially prolonging Swelling or hypersensitivity reactions. On the other hand, intervals that are too long may reduce cumulative benefits. As noted earlier, Collagen stimulation is a gradual process — adjusting within a 4–6 week window based on your recovery pace is generally the most efficient approach. That said, if you are pregnant or breastfeeding, have active inflammation at the treatment site, or have a keloid-prone constitution, it is important to postpone and consult with a medical professional first.

Frequently Asked Questions

Q. Can I receive all three procedures at the same time?

A. Combining two procedures during the same period is not recommended. Since their mechanisms of action differ, Swelling or hypersensitivity reactions can compound, and it becomes difficult to distinguish which procedure produced which result. It's better to prioritize your skin concerns and proceed with one at a time.

Q. Which one shows results the fastest?

A. Rejuran tends to show improvements in Skin Texture tone relatively quickly. Juvelook's volume and Elasticity benefits emerge more gradually over time. RE2O shows greater variability in outcomes between individuals, making it difficult to generalize.

Q. What is the Downtime after each procedure?

A. All three may involve mild redness or minor Swelling at the injection sites for a few days, with individual variation depending on recovery ability. It's advisable to avoid saunas and intense exercise for about a day following the procedure.

Q. Is it safe to receive these procedures during pregnancy?

A. Skin booster procedures are not recommended during pregnancy or breastfeeding. Hormonal changes make outcomes difficult to predict, and safety data in these populations is not sufficient — postponing is the safer choice. This article is intended for general informational purposes only. The appropriate procedure and timing for your specific skin condition should be determined in consultation with a qualified medical professional.

Further Reading

• Rejuran vs. Revive — Comparing Mechanisms, Indications, and How to Choose
• "What's the Difference Between Rejuran and Revive?" — The Most Common Question in My Practice
• Potenza vs InMode vs Shrink — Which Procedure Is Right for You?
• Botox and Filler Are Not the Same — Grouping Them Together Is Where the Wrong Choice Begins