Still Bruised 3 Days After Rejuran — How Many Out of 47 Patients Actually Experience This?

Still Bruised 3 Days After Rejuran — How Many Out of 47 Patients Actually Experience This?

Let me get straight to the point.

When it comes to side effects from Rejuran,

the cause is far more likely to be the injection technique

than your individual skin type or constitution.

Let me walk you through exactly why that is.

Rejuran Side Effects — What's a Normal Reaction and What Isn't?

Rejuran is a procedure that delivers

PDRN (Polynucleotide) — an active ingredient extracted from salmon DNA —

directly into the Dermis.

Unlike Botox or Filler, Rejuran isn't about

"filling and smoothing" the skin.

It's closer to "regenerating the tissue from within."

That's why the post-procedure response is different, too.

Rather than seeing immediate results like you might with Filler,

it's more common to notice needle marks, Bruising, and Swelling that linger for a few days.

The Real Reason Bruising and Nodules Develop After Rejuran

Last month, I consulted with 47 patients

and followed up on their post-procedure progress.

7 of them developed noticeable Bruising,

and about 3 had nodules — small, bumpy granules you can feel when you press the skin —

that persisted for over a week.

Honestly, this ratio can vary quite a bit

depending on who's performing the procedure.

Here's why.

Rejuran needs to be deposited into the mid-Dermis —

roughly 1.5 to 2mm below the skin surface.

And there's one critical factor here:

inject too shallow, and it stays as a nodule.

Inject too deep, and you nick a blood vessel and cause Bruising.

A patient in her late 30s came in last week.

She'd already had 3 sessions at another clinic,

and she was upset because the small bumps on her cheeks

hadn't gone away for an entire month.

When I felt the area, I could detect a line of tiny granules

running along the injection path.

This is what happens when the product is applied too superficially, repeatedly.

The PDRN doesn't reach the Dermis —

it pools in the upper layers instead.

In my practice, I typically choose between two approaches.

For the full face, I use a 30G needle,

maintaining a consistent depth throughout.

For thinner-skinned areas like around the eyes and mouth,

I switch to a cannula.

Occasionally, as a third option, for patients with a history of nodules,

I split the dose in half and administer it over two sessions,

spaced two weeks apart.

Who Should Be Extra Cautious About Rejuran Side Effects?

It varies by individual, but here's how I generally categorize it.

That said, this doesn't have to be a dealbreaker.

Bruising and mild Swelling typically subside

within 3 to 5 days for most patients,

and nodules can usually be resolved with warm compress and gentle massage

within 2 to 3 weeks.

However, if a nodule hasn't resolved after a month,

it should not be treated with hyaluronidase.

Instead, it requires either a diluted saline injection

or a micro-steroid injection to break it down —

so please make sure to return to the clinic where you had the procedure done.

Three Things to Check Before Your Procedure

Q1. Can I go back to work the day after Rejuran?

A. Needle marks may be slightly visible for 1 to 2 days.

They're generally coverable with makeup,

but if significant Bruising occurs, it can last up to a week.

If you have an important event coming up,

it's safest to schedule your procedure at least 5 days in advance.

Q2. How many sessions does it take to see results?

A. The standard protocol is typically

3 sessions spaced 3 to 4 weeks apart.

I've seen quite a few patients come in saying

they "didn't notice any effect" after one or two sessions elsewhere —

and after 2 to 3 more sessions here,

they say their Skin Texture has genuinely changed.

Rejuran requires cumulative sessions

for true dermal remodeling to take place,

so it's difficult to make a fair judgment after just one round.

Q3. I have a nodule — is it okay to leave it alone?

A. You can monitor it for up to 2 to 3 weeks.

Try applying a warm towel twice a day,

5 minutes each time, with a gentle massage.

But if it hasn't resolved after a month,

or if the area becomes red or painful,

please come in to see us right away.

Left untreated, it can harden into fibrosis.

If you're unsure about which concentration is right for you, feel free to send a photo of your skin via KakaoTalk. This has been Dr. Wi Young-jin.