Pain-Free Rejuran — Where HB Plus and Healer Part Ways
If you're looking for a pain-free Rejuran experience, HB Plus is generally the go-to answer. That said, the results feel different from Healer — so choose based on your own goals.
If you've been researching Rejuran but the thought of the Pain is holding you back, HB Plus is an option that comes up often. To cut straight to the point: HB Plus is the lower-Pain version, while Healer is the original PN-based formula — and the two deliver subtly different results. The right choice really depends on your skin condition and Pain tolerance.
The Rejuran Lineup — What's Different Between Healer, HB, and HB Plus?
Under the Rejuran name, there are actually several product lines. They all share a Polynucleotide (PN) base, but differ in concentration and function:
| Line | Key Ingredients | Primary Target | Pain Level |
|---|---|---|---|
| Rejuran Healer | PN 2% | Dermis Recovery & Skin Texture | Relatively highest |
| Rejuran HB | PN + HA complex | Moisturizing & Skin Texture | Moderate |
| Rejuran HB Plus | PN + HA + anesthetic agent | Pain relief + Moisturizing | Lowest |
Healer is the original formula, while HB and HB Plus represent line extensions designed to reduce the discomfort associated with the procedure.
PN (Polynucleotide)*: A DNA fragment extracted from salmon testes, known for stimulating skin cell proliferation and Recovery.
How HB Plus Reduces Pain
There are two main reasons HB Plus tends to be less uncomfortable than standard Rejuran:
- Built-in local anesthetic — blocks Pain signals during the procedure
- HA-adjusted viscosity — reduces injection pressure and discomfort
Because an anesthetic agent is included, it's important to disclose any allergy history beforehand. If you have a known lidocaine allergy, standard Healer is recommended over HB Plus.
Lidocaine*: A local anesthetic used to minimize procedural Pain. Allergic reactions, though rare, are possible — which is why disclosing your allergy history before the procedure matters.
The safety guidelines for non-surgical aesthetic procedures also emphasize checking for allergies prior to any procedure involving anesthetic agents.
Results — Same Lineup, but Different Outcomes
Here's a breakdown of how the three lines compare in terms of results:
| Category | Healer | HB | HB Plus |
|---|---|---|---|
| Dermis regeneration intensity | Strong | Moderate | Moderate |
| Immediate Moisturizing effect | Mild | Strong | Strong |
| Skin Texture & Elasticity improvement | Strong | Moderate | Moderate |
| Visible change per session | Greater | Moderate | Moderate |
| Recommended sessions | 3–4 sessions | 2–3 sessions | 2–3 sessions |
If deeper dermal regeneration is your priority, Healer is the general recommendation. If you want to feel the Moisturizing benefits quickly, the HB line tends to be the better fit. HB Plus delivers results similar to HB, with reduced procedural discomfort.
A session interval of 2–4 weeks is generally advised. Please consult with your medical provider based on your skin's Recovery pace and your schedule.
Which Line Is Right for You?
Here's a quick guide based on your situation:
- Low Pain tolerance or first-time patients → HB Plus recommended
- Looking for strong Skin Texture & Elasticity improvement → Healer recommended
- Want to notice Moisturizing and Skin Texture benefits quickly → HB or HB Plus
- Known lidocaine allergy → Healer (no anesthetic added)
- Pregnant or breastfeeding → Procedure not advised (all lines)
- Active Acne or inflammation at the treatment site → Wait until the area has healed
Please consult your medical provider promptly if any of the following apply:
- History of adverse reactions to PN-based procedures
- Diagnosed autoimmune condition
- Currently taking anticoagulants or high-dose vitamin E
The right choice comes down to your skin assessment, Pain threshold, and schedule. Sharing your lifestyle and daily routine during your consultation will help your provider make a more precise recommendation.
Frequently Asked Questions
Q. Is HB Plus less effective than Healer?
A. "Less effective" isn't quite accurate — "different in character" is more precise. HB Plus excels at Pain reduction and delivering Moisturizing improvements, while Healer is stronger for deep dermal regeneration and Skin Texture refinement. If your main goal is immediate hydration, HB Plus is a solid choice. If you're after deeper regeneration, Healer is generally the preferred option.
Q. Which line is best for a first-time patient?
A. Many first-timers who are concerned about discomfort start with HB Plus. The lower procedural burden tends to make the initial experience much more comfortable, and some patients transition to Healer from the second session onward. Ultimately, it comes down to your priorities — Pain comfort vs. intensity of results — so it's worth discussing with your provider.
Q. How long should I wait between sessions?
A. A 2–4 week interval is generally recommended. Depending on Recovery at the treatment site, your overall skin condition, and any overlapping procedures (such as Botox or Filler), the interval may need to be adjusted. Be sure to share your full procedure history during your consultation. Please note that this article is for general informational purposes only. Whether this procedure is right for you should be determined through a direct consultation with a qualified medical provider.
